Chronically Epileptic Human and Rat Neocortex Display a Similar Resistance Against Spreading Depolarization In Vitro
نویسندگان
چکیده
منابع مشابه
Chronically epileptic human and rat neocortex display a similar resistance against spreading depolarization in vitro.
BACKGROUND AND PURPOSE Experimental and clinical evidence suggests that prolonged spreading depolarizations (SDs) are a promising target for therapeutic intervention in stroke because they recruit tissue at risk into necrosis by protracted intracellular calcium surge and massive glutamate release. Unfortunately, unlike SDs in healthy tissue, they are resistant to drugs such as N-methyl-d-aspart...
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Epileptic seizures and cortical spreading depolarization (CSD) are two patterns of electrophysiological activity that can be studied in the healthy and in the injured brain. They can be triggered by the same pathologies, such as stroke, traumatic brain injury and fever, with disruption of the blood brain barrier as a common hallmark. The latter is associated with entry of serum components into ...
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Spreading depolarization of cells in cerebral grey matter is characterized by massive ion translocation, neuronal swelling and large changes in direct current-coupled voltage recording. The near-complete sustained depolarization above the inactivation threshold for action potential generating channels initiates spreading depression of brain activity. In contrast, epileptic seizures show modest ...
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Introduction: Spreading depression (SD) is a propagating wave of depolarization followed by depression of the neuroglial activities and can modulate extracellular dopamine concentrations in the neocortex. It has been shown that the dopaminergic system plays a role in migraine. SD has been suggested as a critical phenomenon in the pathophysiology of migraine. The aim of this study was to investi...
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Very fast oscillations (VFOs, >80 Hz) are important for physiological brain processes and, in excess, with certain epilepsies. Putative mechanisms for VFO include interneuron spiking and network activity in coupled pyramidal cell axons. It is not known whether either, or both, of these apply in pathophysiological conditions. Spontaneously occurring interictal discharges occur in human tissue in...
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ژورنال
عنوان ژورنال: Stroke
سال: 2011
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.111.621581